Neurons are metabolically active cells that generally are dependent on mitochondrial A TP
production to meet their energetic needs. In contrast, other cell types with a high energy …

The biochemical pathways to cell death in chronic and acute forms of neurodegeneration
are poorly understood, limiting the ability to develop effective therapeutic approaches. As …

Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases
such as rheumatoid arthritis ( RA ) are associated with metabolic disruption. This is likely to …

To gain a better understanding of the critical role of mitochondria in cell function, we have
compiled an extensive catalogue of the mitochondrial proteome using highly purified …

Several lines of evidence indicate that mitochondrial reactive oxygen species (ROS) generation
is the major source of oxidative stress in the cell. It has been shown that ROS production …

Recently developed technologies have enabled multi-well measurement of O 2 consumption,
facilitating the rate of mitochondrial research, particularly regarding the mechanism of …

Breakthrough technologies to measure cellular oxygen consumption and proton efflux are
reigniting the study of cellular energetics by increasing the scope and pace with which …

It is known that loss-of-function mutations in the gene encoding Parkin lead to development
of Parkinson disease. Recently, Parkin was found to play an important role in the removal of …

Expression of the human protooncogene bcl-2 protects neural cells from death induced by
many forms of stress, including conditions that greatly elevate intracellular Ca2+. Considering …

Metabolic reprogramming is emerging as a hallmark of the innate immune response, and
the dynamic control of metabolites such as succinate serves to facilitate the execution of …