The breadth and dynamics of the recent financial crisis have led to efforts to develop forward-looking
tools to monitor systemic risk. In this paper we propose a new measure which is an …

Importance The watch-and-wait (WW) strategy aims to spare patients with rectal cancer
unnecessary resection. Objective To analyze the outcomes of WW among patients with rectal …

Standard doses of conventionally fractionated radiation have had minimal to no impact on
the survival duration of patients with locally advanced unresectable pancreatic cancer (LAPC). …

At the root of most fatal malignancies are aberrantly activated transcriptional networks that
drive metastatic dissemination. Although individual metastasis-associated genes have been …

The PhoP-PhoQ two-component system is a well studied bacterial signaling system that
regulates virulence and stress response. Catalytic activity of the histidine kinase sensor protein …

Background and Purpose Stereotactic body radiation therapy delivered using MR-guided
radiotherapy (MRgRT) and automatic breathold gating has shown to improve overall survival …

Background Most patients with metastatic cancer eventually develop resistance to systemic
therapy, with some having limited disease progression (ie, oligoprogression). We aimed to …

Background: The value of neoadjuvant radiotherapy (RT) after 5-fluorouracil with leucovorin,
oxaliplatin, and irinotecan, with or without dose modifications [(m) FOLFIRINOX], for …

Importance Predicting outcomes in patients receiving neoadjuvant therapy for rectal cancer
is challenging because of tumor downstaging. Validated clinical calculators that can estimate …

Purpose Multibeam intensity modulated radiation therapy (IMRT) enhances the therapeutic
index by increasing the dosimetric coverage of the targeted tumor tissues while minimizing …