In most tissues, the precise control of cell migration and cell-cell interaction is of paramount
importance to the development of a functional structure. Several families of secreted …

The development of the cortex is an elaborate process that integrates a plethora of finely
tuned molecular processes ranging from carefully regulated gradients of transcription factors, …

An increasing number of studies, addressing the linguistic abilities of individuals with Down
syndrome (DS) suggest that they exhibit strengths and weaknesses within the linguistic …

Non-coding "ultraconserved" regions containing hundreds of consecutive bases of perfect
sequence conservation across mammalian genomes can function as distant-acting enhancers…

Background Evidence highlights increased susceptibility to thoughts and behaviors related
to suicide (ie suicidal ideation) in the student population, often in co-occurrence with mental …

Ultraconserved enhancer sequences show perfect conservation between human and rodent
genomes, suggesting that their functions are highly sensitive to mutation. However, current …

Astrocyte dysregulation has been implicated in the pathophysiology of schizophrenia (SCZ)
and bipolar disorder (BPD), however the exact nature of astrocytic alterations remains to be …

Deleterious genetic variants in POGZ, which encodes the chromatin regulator Pogo
Transposable Element with ZNF Domain protein, are strongly associated with autism spectrum …

Background Williams (WS) and Down syndromes (DS) are two genetic disorders that
involve intellectual disability (ID) and have been extensively studied over the past decades …

We demonstrate using conditional mutagenesis that Pbx1, with and without Pbx2 +/− sensitization,
regulates regional identity and laminar patterning of the developing mouse neocortex …