Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells

…, L Wang, D Lu, M Katakowski, Q Gao, LH Shen… - Glia, 2005 - Wiley Online Library
The long‐term (4‐month) responses to treatment of stroke in the older adult rat, using rat
bone marrow stromal cells (MSCs), have not been investigated. Retired breeder rats were …

Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke

LH Shen, Y Li, J Chen, A Zacharek… - Journal of Cerebral …, 2007 - journals.sagepub.com
Bone marrow stromal cells (BMSCs) facilitate functional recovery in rats after stroke when
administered acutely (1 day) or subacutely (7 days). In this study, we postponed the time of cell …

[HTML][HTML] Lack of PTEN sequesters CHK1 and initiates genetic instability

J Puc, M Keniry, HS Li, TK Pandita, AD Choudhury… - Cancer cell, 2005 - cell.com
Pten −/− cells display a partially defective checkpoint in response to ionizing radiation (IR).
The checkpoint defect was traced to the ability of AKT to phosphorylate CHK1 at serine 280, …

Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action

Y Cheng, L Shen, J Zhang - ACTA pharmacologica sinica, 2005 - nature.com
In the present paper, we overview the discovery of new biological activities induced by
ginsenoside Rg1 and Rb1 and discuss possible mechanisms of action. Both compounds could …

Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke

LH Shen, Y Li, J Chen, J Zhang, P Vanguri… - Neuroscience, 2006 - Elsevier
The present study investigates the induction of axon and myelin remodeling as a possible
mechanism by which treatment of stroke with bone marrow stromal cells improves …

One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke

LH Shen, Y Li, J Chen, Y Cui, C Zhang, A Kapke, M Lu… - Stroke, 2007 - Am Heart Assoc
Background and Purpose— We sought to evaluate the long-term effects of bone marrow
stromal cell (BMSC) treatment on retired breeder rats with stroke. Methods— Female retired …

Down‐regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells …

LH Shen, Y Li, Q Gao, S Savant‐Bhonsale, M Chopp - Glia, 2008 - Wiley Online Library
The glial scar, a primarily astrocytic structure bordering the infarct tissue inhibits axonal
regeneration after stroke. Neurocan, an axonal extension inhibitory molecule, is up‐regulated in …

Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts

R Qu, Y Li, Q Gao, L Shen, J Zhang, Z Liu… - …, 2007 - Wiley Online Library
Treatment of rodents after stroke with bone marrow stromal cells (BMSCs) improves functional
outcome. However, the mechanisms underlying this benefit have not been ascertained. …

[HTML][HTML] Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

J Gao, S Peng, X Shan, G Deng, L Shen, J Sun… - Cell death & …, 2019 - nature.com
Radiation-induced lung injury (RILI) is one of the most common and fatal complications of
thoracic radiotherapy, whereas no effective interventions are available. Andrographolide, an …

Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex

L Alland, G David, H Shen-Li, J Potes… - … and cellular biology, 2002 - Taylor & Francis
Silencing of gene transcription involves local chromatin modification achieved through the
local recruitment of large multiprotein complexes containing histone deacetylase (HDAC) …