Complex biological systems and cellular networks may underlie most genotype to phenotype
relationships. Here, we review basic concepts in network biology, discussing different …

This article summarizes technical advances contained in the fifth major release of the Q-Chem
quantum chemistry program package, covering developments since 2015. A …

Despite decades of accumulated knowledge about proteins and their post-translational
modifications (PTMs), numerous questions remain regarding their molecular composition and …

… We thank members of the Vidal laboratory and the participants of the ORFeome Meeting for
discussions; the sequencing staff at Agencourt Biosciences for technical assistance; E. Smith …

A network of disorders and disease genes linked by known disorder–gene associations
offers a platform to explore in a single graph-theoretic framework all known phenotype and …

Background Among breast cancers without human epidermal growth factor receptor 2 (HER2)
amplification, overexpression, or both, a large proportion express low levels of HER2 that …

Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome …

The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the ability
to differentiate into virtually all adult cell types are not well understood. Polycomb group (…

To initiate studies on how protein-protein interaction (or “interactome”) networks relate to
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …

… Cai and M. Temple, for technical support and computation resources; members of the Vidal
laboratory and J. Dekker for suggestions; T. Clingingsmith for administrative assistance; and …