User profiles for Matthew Klein
Matthew Klein MD/PhDISMMS Verified email at mssm.edu Cited by 3064 |
A genomic storm in critically injured humans
…, MG Jeschke, MC López, MB Klein… - Journal of Experimental …, 2011 - rupress.org
Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …
Genomic responses in mouse models poorly mimic human inflammatory diseases
…, MA West, MG Jeschke, MB Klein… - Proceedings of the …, 2013 - National Acad Sciences
A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-…
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-…
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
Both increases and decreases in methyl CpG–binding protein 2 (MeCP2) levels cause
neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (…
neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (…
PSD-95 is required for activity-driven synapse stabilization
The activity-dependent regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
(AMPA)-type glutamate receptors and the stabilization of synapses are critical to synaptic …
(AMPA)-type glutamate receptors and the stabilization of synapses are critical to synaptic …
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
N Vo, ME Klein, O Varlamova… - Proceedings of the …, 2005 - National Acad Sciences
MicroRNAs (miRNAs) regulate cellular fate by controlling the stability or translation of mRNA
transcripts. Although the spatial and temporal patterning of miRNA expression is tightly …
transcripts. Although the spatial and temporal patterning of miRNA expression is tightly …
Flexor tendon healing in vitro: effects of TGF-β on tendon cell collagen production
MB Klein, N Yalamanchi, H Pham, MT Longaker… - The Journal of hand …, 2002 - Elsevier
Flexor tendon healing is complicated by adhesions to the surrounding sheath. Transforming
growth factor beta (TGF-β) is a cytokine with numerous activities related to wound healing. …
growth factor beta (TGF-β) is a cytokine with numerous activities related to wound healing. …
Patterns and outcomes of pediatric facial fractures in the United States: a survey of the National Trauma Data Bank
…, RA Hopper, J Wang, FP Rivara, MB Klein - Journal of the American …, 2008 - Elsevier
BACKGROUND: Pediatric trauma involving the bones of the face is associated with severe
injury and disability. Although much is known about the epidemiology of facial fractures in …
injury and disability. Although much is known about the epidemiology of facial fractures in …
Epidemiology and impact of scarring after burn injury: a systematic review of the literature
…, ST Mason, K Schomer, MB Klein - Journal of burn care & …, 2012 - academic.oup.com
The purpose of this study was to perform a systematic review of the existing literature on the
incidence of hypertrophic scarring and the psychosocial impact of burn scars. In a …
incidence of hypertrophic scarring and the psychosocial impact of burn scars. In a …
Fournier's Gangrene: population based epidemiology and outcomes
…, FP Rivara, JA Broghammer, MB Klein… - The Journal of …, 2009 - auajournals.org
Purpose : Case series have shown a Fournier's gangrene mortality rate of 20% to 40% with
an incidence of as high as 88% in some studies. Because to our knowledge there are no …
an incidence of as high as 88% in some studies. Because to our knowledge there are no …
The association between fluid administration and outcome following major burn: a multicenter study
MB Klein, D Hayden, C Elson, AB Nathens… - Annals of …, 2007 - journals.lww.com
Objective: To determine patient and injury variables that influence fluid requirements following
burn injury and examine the association between fluid volume received and outcome. …
burn injury and examine the association between fluid volume received and outcome. …