The effect of introducing internal cavities on protein native structure and global stability has
been well documented, but the consequences of these packing defects on folding free-…

Parallel β-sheet-containing repeat proteins often display a structural motif in which conserved
asparagines form a continuous ladder buried within the hydrophobic core. In such “…

Many repeat proteins contain capping motifs, which serve to shield the hydrophobic core from
solvent and maintain structural integrity. While the role of capping motifs in enhancing the …

A collection of programs is presented to analyze the thermodynamics of folding of linear repeat
proteins using a 1D Ising model to determine intrinsic folding and interfacial coupling free …

Introduction: Pilot projects (“pilots”) are important for testing hypotheses in advance of
investing more funds for full research studies. For some programs, such as Clinical and …

Certain investor types, particularly those approaching or in retirement, care about the income
properties of investment portfolios. This article addresses the income characteristics of …

Calcineurin (CaN) is a heterodimeric Ser/Thr phosphatase. Calcineurin regulates diverse
biological functions, from T-cell activation to critical events in early heart development. The …

Basis risk or residual risk arising from disparity between an index’s estimate of losses and
actual losses is inherent in index-based insurance products. We approximate basis risk as the …

The answer to how much international exposure is advantageous in a domestic portfolio
depends on what the investor assumes about the long-run risk and expected return of the …

The Society of Actuaries (SOA) engaged Kamakura Corporation to help illuminate credit risk
modeling techniques within the life insurance industry. This involved a review of available …