THE ability to attribute mental states to others (‘theory of mind’) pervades normal social
interaction and is impaired in autistic individuals. In a previous positron emission tomography …

Sarcoidosis is a polygenic immune disorder with predominant manifestation in the lung.
Genome-wide linkage analysis previously indicated that the extended major histocompatibility …

Innate resistance against Mycobacterium tuberculosis is thought to depend critically on
engagement of pattern recognition receptors on macrophages. However, the relative contribution …

In light of the marked global health impact of tuberculosis (TB), strong focus has been on
identifying biosignatures. Gene expression profiles in blood cells identified so far are indicative …

Among the first cells to invade a site of infection, polymorphonuclear neutrophils (PMN) play
an important role in the control of numerous infections. While PMN are considered critical for …

Mycobacterium tuberculosis (Mtb) parasitizes host macrophages and subverts host innate
and adaptive immunity. Several cytokines elicited by Mtb are mediators of mycobacterial …

Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung
injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: …

Microarray - assisted gene - expression screens of human macrophages revealed WNT5A, a
homolog of Wingless, a key regulator of Drosophila melanogaster embryonic segmentation …

A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …

IL-12 is a potent inducer of IFN-γ production and promotes a protective cell-mediated immune
response after Mycobacterium tuberculosis infection. Recently, the IL-12-related cytokine …