Infection by HIV-1 involves the fusion of viral and cellular membranes with subsequent
transfer of viral genetic material into the cell. The HIV-1 envelope glycoprotein that mediates …

Two populations of Nkx2-1 + progenitors in the developing foregut endoderm give rise to the
entire postnatal lung and thyroid epithelium, but little is known about these cells because …

Background Ant societies comprise individuals belonging to different castes characterized
by specialized morphologies and behaviors. Because ant embryos can follow different …

Context—Histologic diagnosis of renal neoplasm is usually straightforward by routine light
microscopy. However, immunomarkers may be essential in several contexts, including …

PAX 8 is a transcription factor that is essential for embryonic development of the kidney,
Müllerian organs, and thyroid. It may also have a role in tumor development in these organs. The …

Sequencing efforts led to the identification of somatic mutations that could affect the self-renewal
and differentiation of cancer-initiating cells. One such recurrent mutation targets the …

Histone post-translational modifications impact many aspects of chromatin and nuclear
function. Histone H4 Lys 20 methylation (H4K20me) has been implicated in regulating diverse …

A challenge in the treatment of Staphylococcus aureus infections is the high prevalence of
methicillin-resistant S. aureus (MRSA) strains and the formation of non-growing, dormant ‘…

EZH2 is the catalytic subunit of PRC2, a central epigenetic repressor essential for development
processes in vivo and for the differentiation of embryonic stem cells (ESCs) in vitro. The …

The use of human pluripotent stem cells for laboratory studies and cell-based therapies is
hampered by their tumor-forming potential and limited ability to generate pure populations of …